Welcome to the laboratory of Saurabh Sinha at the University of Illinois, Urbana-Champaign.
Our research focuses on computational approaches to problems in molecular biology. In particular, we are interested in exploring gene regulation, mostly in metazoan genomes. We approach the subject through an integrated analysis of DNA sequence, gene expression, and epigenetic data. We also strive to understand how sequences involved in gene regulation have evolved, and how such evolutionary dynamics may inform the discovery of novel regulatory sequences. Broadly speaking, our work falls in the areas of regulatory and comparative genomics.
Principal Investigator: Saurabh Sinha.
FEATURED NEW RESEARCH: Modeling of gene expression works better when using DNA accessibility data.
P. Peng, M.A.H. Samee, S. Sinha (2014). "Incorporating Chromatin Accessibility Data into Sequence-to-Expression Modeling", Biophysical Journal, Volume 108, Issue 5, 10 March 2015, Pages 1257–1267 [Free full text]