Welcome to the laboratory of Saurabh Sinha at the University of Illinois, Urbana-Champaign.
Our research focuses on computational approaches to problems in molecular biology. In particular, we are interested in exploring gene regulation, mostly in metazoan genomes. We approach the subject through an integrated analysis of DNA sequence, gene expression, and epigenetic data. We also strive to understand how sequences involved in gene regulation have evolved, and how such evolutionary dynamics may inform the discovery of novel regulatory sequences. Broadly speaking, our work falls in the areas of regulatory and comparative genomics.
Principal Investigator: Saurabh Sinha.
FEATURED RECENT RESEARCH:
Random walks on biological networks help understand gene sets
C. A. Blatti and S. Sinha (2016) "Characterizing Gene Sets using Discriminative Random Walks with Restart on Heterogeneous Biological Networks", Bioinformatics, ", 32(14):2167-75. . [Full text].
Accounting for DNA shape at binding sites helps predict gene expression
Pei-chen Peng and S. Sinha (2016). "Quantitative modeling of gene expression using DNA shape features of binding sites.", Nucleic Acids Res. 44(13):e120. [Free full text]
How "big" is genomics going to get?
Z. D. Stephens, S. Y. Lee, F. Faghri, R. H. Campbell, C. Zhai, M. J. Efron, R. Iyer, M. C. Schatz*, S. Sinha*, G. E. Robinson* (2015). *Co-corresponding authors. "Big Data: Astronomical or Genomical?", PLoS Biology, 13(7):e1002195. [Free full text]