Welcome to the laboratory of Saurabh Sinha at the University of Illinois, Urbana-Champaign.
Our research focuses on computational approaches to problems in molecular biology. In particular, we are interested in exploring gene regulation, mostly in metazoan genomes, and in the biological contexts of development, behavior and cancer. We approach the subject through an integrated analysis of DNA sequence, gene expression, and epigenetic data. We also strive to understand how sequences involved in gene regulation have evolved. Broadly speaking, our work falls in the areas of regulatory and comparative genomics.
Principal Investigator: Saurabh Sinha.
FEATURED RECENT RESEARCH:
Graphical models help identify major transcriptional regulators of drug response variation
Hanson, C., Cairns, J., Wang, L., & Sinha, S. (2018). Principled multi-omic analysis reveals gene regulatory mechanisms of phenotype variation. Genome Res, 28(8), 1207-1216. doi:10.1101/gr.227066.117. [Free full text]
An SVM model helps improve gene expression signature matching across cell lines
Xiao, J., Blatti, C., & Sinha, S. (2018). SigMat: a classification scheme for gene signature matching. Bioinformatics, 34(13), i547-i554. doi:10.1093/bioinformatics/bty251. [Free full text]
Multi-species analysis reveals shared molecular roots of social behavior
Saul, M. C., Blatti, C., Yang, W., Bukhari, S. A., Shpigler, H. Y., Troy, J. M., . . . Sinha, S. (2018). Cross-species systems analysis of evolutionary toolkits of neurogenomic response to social challenge. Genes Brain Behav, e12502. doi:10.1111/gbb.12502. [Abstract]